Overview
Manufactured by Galderma, Restylane Refyne is an advanced dermal filler designed to combat visible signs of aging. Utilizing Optimal Balance Technology (OBT), this non-animal cross-linked hyaluronic acid gel integrates smoothly into the skin. Formerly known as Emervel Classic, it provides a flexible correction that supports natural facial expressions while delivering a youthful and revitalized appearance.
Composition & Rheology
- Cross-linked Hyaluronic Acid: 20 mg/ml
- Cross-linking agent: BDDE
- Lidocaine hydrochloride: 0.3% (for pain relief)
- Technology: Optimal Balance Technology (OBT)
- Packaging: 1 pre-filled 1ml syringe
Indications
This aesthetic solution is ideal for individuals with thin to normal skin seeking to address moderate facial aging. It is primarily used to smooth out nasolabial folds (smile lines) and marionette lines. Additionally, it helps restore lost facial volume and redefines facial contours, ensuring a balanced and harmonious aesthetic outcome.
Dosage & Administration
The gel is intended for injection into the mid-to-deep dermis by a qualified practitioner. The rejuvenating effects are noticeable instantly and typically last between 6 to 9 months, with some cases showing benefits up to a year. Longevity depends on individual factors such as age, lifestyle, and skin type.
Storage
Store the product in a clean, dry environment at room temperature (between 2°C and 25°C). Keep away from direct sunlight and do not freeze.
Contraindications
- Allergy or hypersensitivity to hyaluronic acid or lidocaine
- Active skin infections or inflammation near the injection site
- Pregnancy or breastfeeding
- Patients with bleeding disorders or on specific antibiotic treatments
- Individuals prone to keloid scarring or suffering from autoimmune conditions












